Hesperetin Activates the Notch1 Signaling Cascade, Causes Apoptosis, and Induces Cellular Differentiation in Anaplastic Thyroid Cancer

Academic Article


  • Methods: A unique ATC cell line HTh7 was used to evaluate the drug effects of hesperetin. The Notch1 activating function and cell proliferation were evaluated. The mechanism of growth regulation was investigated by the detection of apoptotic markers. The expression levels of thyrocyte-specific genes were quantified for ATC redifferentiation.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Patel PN; Yu XM; Jaskula-Sztul R; Chen H
  • Start Page

  • 497
  • End Page

  • 504
  • Volume

  • 21
  • Issue

  • 4