Idiotypic network connectivity and a possible cause of myasthenia gravis.

Academic Article

Abstract

  • Extensive idiotypic connectivity has been discovered between the antibodies composing the immune responses against the acetylcholine receptor (AChR) and alpha-1,3-dextran. The idiotypic connections form an elaborate network linking these disparate antigen systems, and there is an hierarchical organization of the antibodies in this network. The key anti-Ids that interconnect these two responses are more crossreactive, lower-affinity antibodies. Interestingly, 15% of patients with MG, which is caused by autoantibodies against the AChR, have serum antibodies against DEX. Control sera are negative for anti-DEX antibodies. Certain anti-DEX antibodies also bind to anti-AChR antibodies via idiotypic interactions. These findings suggest a model for the initiation of autoimmunity in MG. Antibodies made in response to DEX epitopes on the surface of certain bacteria would elicit the production of anti-Ids. However, some of these anti-Ids would also be autoantibodies against the AChR. Thus, is some circumstances, autoimmunity may develop as a consequence of the normal operation of regulatory idiotypic networks.
  • Published In

    Keywords

  • Animals, Antibodies, Monoclonal, Autoantibodies, Dextrans, Humans, Immunization, Immunoglobulin Idiotypes, Mice, Myasthenia Gravis, Receptors, Cholinergic
  • Author List

  • Dwyer DS; Vakil M; Kearney JF
  • Start Page

  • 1310
  • End Page

  • 1318
  • Volume

  • 164
  • Issue

  • 4