Human blood monocytes and platelets share a cell surface component.

Academic Article


  • We describe a surface determinant shared by human monocytes and cells of the megakaryocytic axis that has been identified using a mouse monoclonal antibody. This monocyte-platelet antigen (MPA) is expressed on all (greater than 99%) of peripheral blood monocytes, platelets, and megakaryocytes. It is also expressed weakly on the monocytic cell line U937 and the promyelocytic line HL60 and is present on cells from 3 of 4 AML patients examined. It is absent from polymorphonuclear leukocytes, T and B lymphocytes, erythrocytes, and a panel of hematopoietic cell lines. MPA is stripped from monocyte membranes with pronase and is reexpressed overnight. The determinant is carried on a noncovalently linked biomolecular complex with molecular weights of 93,000 and 135,000.
  • Published In

  • Blood  Journal
  • Keywords

  • Animals, Antibodies, Monoclonal, Antigens, Surface, Blood Platelets, Haplorhini, Humans, Leukemia, Myeloid, Mice, Mice, Inbred BALB C, Molecular Weight, Monocytes, Pronase
  • Author List

  • Burckhardt JJ; Anderson WH; Kearney JF; Cooper MD
  • Start Page

  • 767
  • End Page

  • 771
  • Volume

  • 60
  • Issue

  • 3