Fasting plasma glucose predicts survival and angiographic progression in high-risk postmenopausal women with coronary artery disease

Academic Article

Abstract

  • Background: We studied the association of baseline fasting plasma glucose (FPG) levels with survival and coronary artery disease (CAD) progression among postmenopausal women without unstable angina. Methods: Women were recruited from seven centers in the Women's Angiographic Vitamin and Estrogen Trial (WAVE) (n = 423). Event follow-up was available for 400 women (65.1 ± 8.5 years, 66% white, 92% hypertensive, 19% smokers, 67% hypercholesterolemic). Thirty-eight percent of the women had diabetes or FPG > 125 mg/dL, and 21% had a fasting glucose 100-125 mg/dL. Follow-up angiography was performed in 304 women. Cox regression was used to model survival from a composite outcome of death or myocardial infarction (D/MI, 26 events; median follow-up 2.4 years). Angiographic progression was analyzed quantitatively using linear regression accounting for baseline minimum lumen diameter (MLD), follow-up time, and intrasubject correlations using generalized estimating equations. Regression analyses were adjusted for follow-up time, baseline age, treatment assignment, and Framingham risk (excluding diabetes). Results: Women with impaired fasting glucose/diabetes mellitus (IFG/DM) had a relative risk (RR) of D/MI of 4.2 (p = 0.009). In all women, each 10 mg/dL increase in FPG was associated with an 11% increase (p < 0.001) in the hazard of D/MI. Each 10 mg/dL increase in FPG was associated with a 6.8 μm decrease in MLD over the follow-up period (p = 0.005). Conclusions: Higher FPG is associated with increased risk of D/MI and greater narrowing of the coronary lumen in women with CAD. Aggressive monitoring of glucose levels may be beneficial for secondary CAD prevention. © Mary Ann Liebert, Inc.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Vaidya D; Kelemen MD; Bittner V; Tardif JC; Thompson P; Ouyang P
  • Start Page

  • 228
  • End Page

  • 234
  • Volume

  • 16
  • Issue

  • 2