Chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissues characterized by the presence of nodular, verrucous lesions, often of the lower extremities. Upon histopathologic examination of infected tissues, the characteristic finding is single or multiple muriform cells, also called sclerotic bodies. The term muriform designates the presence of vertical and horizontal septa of the cells. These muriform cells are dark brown, septate fungal cells that resemble yeast forms (Fig. 1). Chromoblastomycosis is caused by several species of dematiaceous, or pigmented, fungi, of which the most common causative organism is Fonsecaea pedrosoi. The disease is usually chronic, localized, and is rarely life-threatening. Surgical resection and cryotherapy are effective for small lesions, while antifungal agents, including itraconazole and terbinafine, are sometimes effective in more extensive disease.