The Renin-Angiotensin System

Academic Article


  • TIGERSTEDT and Bergman established a role for the kidney in blood-pressure regulation at the close of the 19th century. In a classic experiment, they produced hypertension in dogs by injecting a crude extract of kidney, which they called renin.1 Goldblatt called the attention of modern investigators to renal mechanisms of blood-pressure control by producing hypertension in the dog by clamping the renal artery.2 This experiment suggested the release of a pressor substance from the kidney when its circulation was impaired. Since that time, a cascade of enzymes, peptide and steroid hormones and cofactors belonging to the renin–angiotensin–aldosterone system have been. © 1974, Massachusetts Medical Society. All rights reserved.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Oparil S; Haber E
  • Start Page

  • 389
  • End Page

  • 401
  • Volume

  • 291
  • Issue

  • 8