O-GLCNAC'S role in neurological disorders and its therapeutic implications

Academic Article


  • The O-linked N-acetylglucosamine (O-GlcNAc) modification of several neuronal proteins has been identified. The identified proteins play a significant role in multiple neuropathologies, including Alzheimer's disease (AD), Parkinson's disease, amyotrophic lateral sclerosis (ALS) and prion disease. Additionally, O-GlcNAc proteins are also implicated in synaptosomal transport and proteasome machinery that links it to multiple protein aggregates of neuronal disorders. More importantly, the two enzymes involved in O-GlcNAc dynamism, O-GlcNAc transferase and hydrolase, are both enriched in the brain, and genes encoding these two enzymes are frequently found in the regions of mutations of neurological diseases. This review highlights O-GlcNAc's role in neurological disorders and suggests future implications of the therapeutic modulation of O-GlcNAc.
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    Digital Object Identifier (doi)

    Author List

  • Patel DM; Whisenhunt TR; Markert JM
  • Start Page

  • 561
  • End Page

  • 568
  • Volume

  • 39
  • Issue

  • 8