Genistein inhibition of the growth of human breast cancer cells: Independence from estrogen receptors and the multi-drug resistance gene

Academic Article

Abstract

  • The effect of isoflavones on the growth of the human breast carcinoma cell lines, MDA-468 (estrogen receptor negative), and MCF-7 and MCF-7-D-40 (estrogen receptor positive), has been examined. Genistein is a potent inhibitor of the growth of each cell line (IC50 values from 6.5 to 12.0 μg/ml), whereas biochanin A and daidzein are weaker growth inhibitors (IC50 values from 20 to 34 μg/ml). The isoflavone β-glucosides, genistin and daidzin, have little effect on growth (IC50 values > 100 μg/ml). The presence of the estrogen receptor is not required for the isoflavones to inhibit tumor cell growth (MDA-468 vs MCF-7 cells). In addition, the effects of genistein and biochanin A are not attenuated by overexpression of the multi-drug resistance gene product (MCF-7-D40 vs MCF-7 cells). © 1991.
  • Digital Object Identifier (doi)

    Author List

  • Peterson G; Barnes S
  • Start Page

  • 661
  • End Page

  • 667
  • Volume

  • 179
  • Issue

  • 1