The evolution of immune memory and germinal centers

Academic Article


  • Antibody responses in homoiothermic and poikilothermic vertebrates are significantly different in their heterogeneity and affinity range, and in the speed of the secondary response following repeated antigenic stimulation. This article presents the hypothesis that the evolutionary development of unique lymphoid structures, the germinal centers, in combination with the development of a distinct B-cell lineage, is a determining feature of these differences. © 1992.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Nahm MH; Kroese FGM; Hoffmann JW
  • Start Page

  • 438
  • End Page

  • 441
  • Volume

  • 13
  • Issue

  • 11