Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating units

Academic Article


  • Background: Streptococcus pneumoniae serotype 11D capsular polysaccharide (CPS) structure is unknown. Results: Serotype 11D PS contains two different repeating units; one has αGlcNAc, and the other contains αGlc. Conclusion: The 11D CPS is due to the bispecific glycosyltransferase WcrL. Based on codon 112, WcrL can transfer αGlc, αGlcNAc, or both. Significance: Minimal genetic changes can make bacteria produce different polysaccharides. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Oliver MB; Jones C; Larson TR; Calix JJ; Zartler ER; Yother J; Nahm MH
  • Start Page

  • 21945
  • End Page

  • 21954
  • Volume

  • 288
  • Issue

  • 30