Detection of high incidence of K-ras oncogenes during human colon tumorigenesis.

Academic Article

Abstract

  • RNAse A mismatch cleavage analysis of 66 primary human colon tumors reveals a high incidence of K-ras genes with mutations at position 12. No apparent correlation was found between the presence of mutant oncogenes and the degree of invasiveness of the tumours but evidence for ras mutational activation in premalignant tissue was obtained.
  • Published In

  • Nature  Journal
  • Keywords

  • Adenocarcinoma, Adenoma, Aged, Aged, 80 and over, Codon, Colonic Neoplasms, Female, Humans, Male, Middle Aged, Mutation, Nucleic Acid Hybridization, Oncogenes, RNA, RNA, Complementary, Ribonuclease, Pancreatic
  • Digital Object Identifier (doi)

    Author List

  • Forrester K; Almoguera C; Han K; Grizzle WE; Perucho M
  • Start Page

  • 298
  • End Page

  • 303
  • Volume

  • 327
  • Issue

  • 6120