Abnormal lactate dehydrogenase isoenzyme pattern in a critically ill patient.

Academic Article

Abstract

  • We have described a patient who had an abnormal isoenzyme of lactate dehydrogenase in both serum and tissue. The presence of LD6 is indicative of a poor prognosis. Some of the biochemical characteristics of the isoenzyme are (1) LD6 is not an artifact, (2) it contains an M subunit but not an H subunit, and (3) it is not an immunoglobulin complex. We believe LD6 may arise during episodes of severe shock as lysosomes rupture and is either a previously sequestered lysosomal LD or is a lysosomal modification of LD5.
  • Published In

    Keywords

  • Acidosis, Electrophoresis, Agar Gel, Humans, Infection, Isoenzymes, L-Lactate Dehydrogenase, Liver, Male, Middle Aged, Muscles, Prognosis, Shock
  • Author List

  • Robinson CA; Ketchum CH; Grizzle WE; Hall LM; Alexander CB
  • Start Page

  • 921
  • End Page

  • 923
  • Volume

  • 77
  • Issue

  • 7