How does endothelin induce vascular oxidative stress in mineralocorticoid hypertension?

Academic Article


  • Endothelin and reactive oxygen species have been identified as important mediators in the pathogenesis of hypertension and associated end-organ damage. In the present issue of Clinical Science, Callera and co-workers have provided new evidence that endothelin stimulates mitochondria to generate reactive oxygen species in the vascular wall during mineralocorticoid-induced hypertension in the rat. These studies open a new line of investigation that could be important for the development of therapeutic strategies; however, there still remains a great deal of uncertainty about the mechanisms that define the relationship between endothelin and oxidative stress in hypertension. © 2006 The Biochemical Society.
  • Authors

    Published In

  • Clinical Science  Journal
  • Digital Object Identifier (doi)

    Author List

  • Pollock DM
  • Start Page

  • 205
  • End Page

  • 206
  • Volume

  • 110
  • Issue

  • 2