Small Atrial Natriuretic Peptide Analogs: Design, Synthesis, and Structural Requirements for Guanylate Cyclase Activation

Academic Article

Abstract

  • Structure/activity studies on atrial natriuretic peptide ANP(1–28) have highlighted three portions of the native molecule as necessary for its biological responses. We have linked these three regions and excised the remaining segments to produce a family of small analogues (less than half the size of the parent) which demonstrate the full range of ANP's actions. Importantly, these compounds act at both major types of ANP receptor. Two critical modifications lead to more potent analogues; both involve expanding the cyclic portion of the molecule. Further optimization of one of these modified structures leads to A68828, a full ANP agonist which shows promise as a preventative agent against acute renal failure. © 1992, American Chemical Society. All rights reserved.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Von Geldern TW; Rockway TW; Davidsen SK; Budzik GP; Bush EN; Chu-Moyer MY; Devine EM; Holleman WH; Johnson MC; Lucas SD
  • Start Page

  • 808
  • End Page

  • 816
  • Volume

  • 35
  • Issue

  • 5