Gene delivery into primary T cells: Overview and characterization of a transgenic model for efficient adenoviral transduction

Academic Article

Abstract

  • Technologies for transfer of exogenous genes into primary T cells have been limited until recently. The introduction of new approaches for gene transfer via different viral vectors has expanded the options for genetic manipulation of primary T cells and has provided powerful tools for studies of T cell activation and differentiation. We provide a brief overview of the systems currently available and contrast the advantages and disadvantages of each. We also describe a new transgenic model that enables highly efficient gene delivery into primary T cells by nonreplicating adenoviral vectors.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Hurez V; Hatton RD; Oliver J; Matthews RJ; Weaver CT
  • Start Page

  • 131
  • End Page

  • 141
  • Volume

  • 26
  • Issue

  • 1-3