Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses.

Academic Article

Abstract

  • Marginal zone (MZ) and B1 B lymphocytes participate jointly in the early immune response against T-independent (TI) particulate antigens. Here we show that blood-derived neutrophil granulocytes and CD11c(lo) immature dendritic cells (DC) are the primary cells that efficiently capture and transport particulate bacteria to the spleen. In a systemic infection, CD11c(lo) DC, but not neutrophils, provide critical survival signals, which can be inhibited by TACI-Fc, to antigen-specific MZ B cells and promote their differentiation into IgM-secreting plasmablasts. In a local TI response, peritoneal cavity macrophages provide similar support to B1 B-derived Ag-specific blasts. In the absence of soluble TACI ligands, Ag-activated MZ- and B1-derived blasts lack survival signals and undergo apoptosis, resulting in severely impaired antibody responses.
  • Published In

  • Immunity  Journal
  • Keywords

  • Adoptive Transfer, Animals, Antigen Presentation, Antigens, T-Independent, Apoptosis, B-Lymphocyte Subsets, Bacteria, Blood Cells, CD11c Antigen, Cell Differentiation, Cells, Cultured, Chemotaxis, Leukocyte, Dendritic Cells, Immunoglobulin M, Immunologic Deficiency Syndromes, Lymphocyte Activation, Macrophages, Peritoneal, Membrane Proteins, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Neutrophils, Plasma Cells, Receptors, Tumor Necrosis Factor, Spleen, Transmembrane Activator and CAML Interactor Protein
  • Author List

  • Bal√°zs M; Martin F; Zhou T; Kearney J
  • Start Page

  • 341
  • End Page

  • 352
  • Volume

  • 17
  • Issue

  • 3