Aging with HIV is now possible due to pharmacological advances that are greatly extending life. However, information on aging with HIV is only recently emerging, with little information available about the spiritual lives of those aging with this disease. This pilot study assessed spiritual, psychosocial, and health-related factors in 50 HIVpositive and 50 HIV-negative adults between 30 and 65 years old. The convention of 50 years and over is used in HIV research to indicate older adults and was used in this study as well. Between-group analyses did not reveal differences on attendance of religious events or importance of spirituality. Within-group analyses of the HIV-positive group did show several positive relationships between health-related factors and spirituality; however, age and years diagnosed with HIV were not related to the spirituality items. Interestingly, 72% of the HIV-positive participants indicated that their spirituality changed after receiving their diagnosis and 44% considered HIV to be a blessing. As people age with this disease or contract it in later life, it will be important to understand how spirituality will help people to cope with such a stigmatizing disease. Copyright © by The Haworth Press, Inc. All rights reserved.