Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: Amide- and ether-linked tethered dimers with α-amino acid end groups

Academic Article


  • Tethered dimers incorporating natural α-amino acid end groups were synthesized, including examples in which the previously reported esterase-sensitive ester linker was replaced with more stable amide or ether linkers. These compounds remained effective both as inhibitors of NAD synthetase and as potent antibacterial agents for Gram-positive strains. Studies on nonspecific effects, including detergent properties and promiscuous inhibition, suggested little contribution to observed activities. © 2007 American Chemical Society.
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    Author List

  • Velu SE; Mou L; Luan CH; Yang ZW; DeLucas LJ; Brouillette CG; Brouillette WJ
  • Start Page

  • 2612
  • End Page

  • 2621
  • Volume

  • 50
  • Issue

  • 11