Azathioprine hypersensitivity. Case report and review of the literature

Academic Article


  • Fever in a transplant recipient is an important sign of graft rejection or infection. Rarely, fever may result from an immunosuppressive agent used to prevent graft rejection. A case of fever, rigors, arthralgias, and myalgias is reported in a cardiac transplant recipient in whom azathioprine therapy was recently begun. These findings resolved on discontinuation of the azathioprine, recurred on rechallenge, and were most consistent with a hypersensitivity reaction. The clinical spectrum of reported azathioprine hypersensitivity reactions is reviewed. © 1988.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Anthony Saway P; Heck LW; Bonner JR; Kirklin JK
  • Start Page

  • 960
  • End Page

  • 964
  • Volume

  • 84
  • Issue

  • 5