Bromination, Chlorination, and Nitration of Isoflavonoids

Academic Article

Abstract

  • Isoflavones have been shown to be beneficial in several chronic diseases in which oxidants are involved. Isoflavones are weak antioxidants when tested in vitro in the context of scavenging lipid peroxyl radicals. However, at sites of inflammation proinftammatory oxidants such as peroxynitrite (ONOO), hypochlorous acid (HOC1), and hypobromous acid (HOBr) are formed that may also react with isoflavones. We present evidence herein, using reverse-phase HPLC-mass spectrometry and proton NMR, that at concentrations of these oxidants formed at these local sites, nitration, chlorination, and bromination of isoflavones occurs.
  • Published In

    Author List

  • Boersma BJ; Barnes S; Patel RP; Kirk M; Muccio D; Darley-Usmar VM
  • Start Page

  • 251
  • End Page

  • 261
  • Volume

  • 807