Respiratory syncytial virus immune globulin intravenous: Indications for use

Academic Article

Abstract

  • Respiratory syncytial virus immune globulin intravenous (RSV-IGIV) has been approved by the Food and Drug Administration for use in the prevention of severe RSV infections in infants and children younger than 24 months with bronchopulmonary dysplasia or a history of premature birth (≤35 weeks of gestation). RSV-IGIV administered monthly during the RSV season resulted in a 41% to 65% reduction in hospitalization rates in two clinical trials; however, RSV-IGIV is costly, and intravenous administration can be logistically demanding. RSV-IGIV should be considered for infants with bronchopulmonary dysplasia who are receiving or have received oxygen therapy in the past 6 months. Infants with gestational ages of 32 weeks or less may also benefit clinically from RSV-IGIV prophylaxis. Immunization with measles- containing vaccines should be delayed for 9 months after the last dose of RSV-IGIV, but no changes need to be made for all other routinely administered vaccines. RSV-IGIV has not been approved for use in children with congenital heart disease, and available data indicate that RSV-IGIV should not be administered to children with cyanotic congenital heart disease because of safety concerns.
  • Published In

  • Pediatrics  Journal
  • Author List

  • Halsey NA; Abramson JS; Chesney PJ; Fisher MC; Gerber MA; Gromisch DS; Kohl S; Marcy SM; Murray DL; Overturf GD
  • Start Page

  • 645
  • End Page

  • 650
  • Volume

  • 99
  • Issue

  • 4