Measles immunization in HIV-infected children

Academic Article

Abstract

  • Children infected with human immunodeficiency virus (HIV) have had high rates of mortality attributable to measles, but until recently, measles vaccine was assumed to be safe for these children. A single fatal case of pneumonia attributable to vaccine type-measles virus has been documented in a young adult with acquired immunodeficiency syndrome. Because a protective immune response often does not develop in severely immunocompromised HIV- infected patients after immunization and some risk of severe complications exists, HIV-infected children, adolescents, and young adults who are severely immunocompromised (based on age-specific CD4 lymphocyte enumeration) attributable to HIV infection should not receive measles vaccine. All other HIV-infected children, adolescents, and young adults who are not severely immunocompromised should received measles-mumps-rubella vaccine.
  • Published In

  • Pediatrics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Halsey NA; Abramson JS; Chesney PJ; Fisher MC; Gerger MA; Marcy SM; Murray DL; Overturf GD; Prober CG; Weiner LB
  • Start Page

  • 1057
  • End Page

  • 1060
  • Volume

  • 103
  • Issue

  • 5 I