To the Editor: Drs. Stagno and Whitley, in their review of cytomegalovirus and Epstein–Barr virus in pregnancy (Nov. 14 issue),1 failed to mention an important mode of cytomegalovirus transmission. Children in day care can serve as a source of infection for seronegative mothers contemplating another pregnancy. The day-care center has been shown to be a fertile ground for cytomegalovirus transmission among children in all socioeconomic strata.2 Cytomegalovirus shedding after infection can persist for months or years in asymptomatic children,3 and intrafamilial spread from children to their seronegative parents occurs readily.4 Families considering a second pregnancy should carefully weigh the risks…. © 1986, Massachusetts Medical Society. All rights reserved.