The clinically available NMDA receptor antagonist dextromethorphan attenuates acute morphine withdrawal in the neonatal rat

Academic Article


  • We investigated the ability of dextromethorphan, a clinically available NMDA receptor antagonist, to attenuate the behaviors and the expression of c-fos mRNA associated with acute morphine withdrawal in the 7-day-old rat. The intensity of the acute morphine withdrawal behaviors and the elevation in c-fos mRNA expression in the brain induced by acute morphine withdrawal were reduced by dextromethorphan. Thus, dextromethorphan can attenuate acute morphine withdrawal in the developing organism. © 2003 Elsevier Science B.V. All rights reserved.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Zhu H; Jenab S; Jones KL; Inturrisi CE
  • Start Page

  • 209
  • End Page

  • 213
  • Volume

  • 142
  • Issue

  • 2