Nuclear accumulation of p53 is a potential marker for the development of squamous cell lung cancer in smokers.

Academic Article

Abstract

  • STUDY OBJECTIVES: To determine whether the nuclear accumulation of p53 in patients with early bronchial neoplasia represents an altered susceptibility for the development of lung cancer. PATIENTS AND MEASUREMENTS: We evaluated the percentage of cells accumulating nuclear p53 immunohistochemically in squamous cell carcinoma (SCC) of the lung, the associated uninvolved bronchial mucosa, and epithelial hyperplasia in 60 archival lung specimens of smokers and in the normal bronchial epithelium and hyperplastic lesions of 60 smokers who had not developed lung cancer. RESULTS: The percentage of cells accumulating p53 was significantly higher in SCC-associated uninvolved bronchial epithelia of (mean [+/- SD], 4 +/- 0.9%) and in specimens from patients with epithelial hyperplasia (mean, 9 +/- 2%) compared to the percentage of cells from the bronchial epithelia of (mean, 0.5 +/- 0.2%) and in specimens from patients with epithelial hyperplasia (mean, 1.5 +/- 0.5%) who were smokers who had not developed lung cancer (p = 0.0002 and p = 0.0004, respectively). We also observed a statistically significant stepwise increase in the percentage of cells accumulating p53 from SCC-associated uninvolved bronchial epithelium to those from a patient with epithelial hyperplasia to those from a patient with SCC (mean, 35 +/- 4%), suggesting the involvement of p53 accumulation in the development of SCC (p
  • Published In

  • Chest  Journal
  • Keywords

  • Aged, Biomarkers, Tumor, Carcinoma, Squamous Cell, Cell Nucleus, Female, Humans, Lung Neoplasms, Male, Smoking, Tumor Suppressor Protein p53
  • Author List

  • Piyathilake CJ; Frost AR; Manne U; Weiss H; Heimburger DC; Grizzle WE
  • Start Page

  • 181
  • End Page

  • 186
  • Volume

  • 123
  • Issue

  • 1