Regulation of adenylyl cyclase in LTP

Academic Article


  • Our results on hippocampal long-term potentiation are considered in the context of Xia et al.'s hypothesis. Whereas the target article proposes presynaptic PKC involvement in adenylyl cyclase activation by phosphorylation of neuromodulin, we suggest an additional postsynaptic role involving RC3/neurogranin. Finally, we examine the possibility that the adenylyl cyclase mutant mouse may display normal learning with a selective impairment of memory.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Roberson ED; Sweatt JD
  • Start Page

  • 485
  • End Page

  • 486
  • Volume

  • 18
  • Issue

  • 3