The dendritic hypothesis for Alzheimer's disease pathophysiology

Academic Article

Abstract

  • Converging evidence indicates that processes occurring in and around neuronal dendrites are central to the pathogenesis of Alzheimer's disease. These data support the concept of a "dendritic hypothesis" of AD, closely related to the existing synaptic hypothesis. Here we detail dendritic neuropathology in the disease and examine how Aβ, tau, and AD genetic risk factors affect dendritic structure and function. Finally, we consider potential mechanisms by which these key drivers could affect dendritic integrity and disease progression. These dendritic mechanisms serve as a framework for therapeutic target identification and for efforts to develop disease-modifying therapeutics for Alzheimer's disease. This article is part of a special issue Dendrites and Disease. © 2013 Elsevier Inc.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Cochran JN; Hall AM; Roberson ED
  • Start Page

  • 18
  • End Page

  • 28
  • Volume

  • 103