Structure and Function of Immunoglobulins

Chapter

Abstract

  • © 2014 Elsevier Inc. All rights reserved.Immunoglobulins (Igs) are heterodimeric proteins consisting of two heavy (H) and two light (L) chains, each of which encodes a V domain and one or more C domains. The V domain is the product of a complex series of gene rearrangement events that endow Igs, as a population, to recognize an almost unlimited array of self and nonself antigens. The H chain C domains encode effector functions that can include activation of complement, binding to Fc receptors, and inducing or maintaining inflammation.
  • Digital Object Identifier (doi)

    International Standard Book Number (isbn) 13

  • 9780128012383