Do adaptive changes in metabolic rate favor weight regain in weight-reduced individuals? An examination of the set-point theory.

Academic Article


  • BACKGROUND: Obese persons generally regain lost weight, suggesting that adaptive metabolic changes favor return to a preset weight. OBJECTIVE: Our objective was to determine whether adaptive changes in resting metabolic rate (RMR) and thyroid hormones occur in weight-reduced persons, predisposing them to long-term weight gain. DESIGN: Twenty-four overweight, postmenopausal women were studied at a clinical research center in four 10-d study phases: the overweight state (phase 1, energy balance; phase 2, 3350 kJ/d) and after reduction to a normal-weight state (phase 3, 3350 kJ/d; phase 4, energy balance). Weight-reduced women were matched with 24 never-overweight control subjects. After each study phase, assessments included RMR (by indirect calorimetry), body composition (by hydrostatic weighing), serum triiodothyronine (T(3)), and reverse T(3) (rT(3)). Body weight was measured 4 y later, without intervention. RESULTS: Body composition-adjusted RMR and T(3):rT(3) fell during acute (phase 2) and chronic (phase 3) energy restriction (P: < 0.01), but returned to baseline in the normal-weight, energy-balanced state (phase 4; mean weight loss: 12.9 +/- 2.0 kg). RMR among weight-reduced women (4771 +/- 414 kJ/d) was not significantly different from that in control subjects (4955 +/- 414 kJ/d; P: = 0.14), and lower RMR did not predict greater 4-y weight regain (r = 0.27, NS). CONCLUSIONS: Energy restriction produces a transient hypothyroid-hypometabolic state that normalizes on return to energy-balanced conditions. Failure to establish energy balance after weight loss gives the misleading impression that weight-reduced persons are energy conservative and predisposed to weight regain. Our findings do not provide evidence in support of adaptive metabolic changes as an explanation for the tendency of weight-reduced persons to regain weight.
  • Keywords

  • Aged, Basal Metabolism, Body Composition, Body Mass Index, Calorimetry, Indirect, Diet, Reducing, Energy Intake, Female, Humans, Kinetics, Middle Aged, Models, Biological, Obesity, Postmenopause, Triiodothyronine, Triiodothyronine, Reverse, Weight Gain, Weight Loss
  • Digital Object Identifier (doi)

    Author List

  • Weinsier RL; Nagy TR; Hunter GR; Darnell BE; Hensrud DD; Weiss HL
  • Start Page

  • 1088
  • End Page

  • 1094
  • Volume

  • 72
  • Issue

  • 5