Hemodynamic effects of a new histamine H2 receptor agonist (impromidine) and antagonist (ranitidine)

Academic Article


  • The current study was designed to evaluate a) the effects of a relatively new histamine H2 receptor antagonist, ranitidine, on H2 mediated increases in canine renal and mesenteric blood flows and b) the effects of a relatively new H2 agonist, impromidine, on canine mesenteric hemodynamics. Ranitidine was nearly 10 times as effective as cimetidine (a widely prescribed H2 antagonist) in inhibiting dimaprit (an H2 agonist) induced increases in renal and mesenteric blood flows. Studies with impromidine revealed that this H2 agonist is about 100 times more potent than dimaprit in producing equivalent increases in mesenteric blood flow. © 1982 The Italian Pharmacological Society.
  • Digital Object Identifier (doi)

    Author List

  • Pollock DM; Banks RO; Jacobson ED
  • Start Page

  • 605
  • End Page

  • 612
  • Volume

  • 14