Cholinergic receptors regulate a voltage-insensitive but Na+-dependent calcium influx pathway in salivary acinar cells.

Academic Article


  • The calcium-sensitive fluorescent probe, quin 2, was employed to investigate the cholinergic receptor regulation of cytosolic free calcium concentration [( Ca2+]i) in isolated rat submandibular acinar cells. Cholinergic receptor stimulation results in a marked and sustained elevation [Ca2+]i. The major component of this response is shown to be due to activation of a calcium influx pathway. There is no evidence in K+-depolarized cells of any voltage-gated calcium influx. Acetylcholine failed to activate the calcium influx pathway in cells bathed in Na+-free solutions. The cholinergic receptors thus regulate a voltage-insensitive but Na+-dependent transport system for calcium entry in submandibular acinar cells.
  • Published In

  • FEBS Letters  Journal
  • Keywords

  • Acetylcholine, Animals, Calcium, Cytosol, Electrophysiology, Male, Meglumine, Membrane Potentials, Osmolar Concentration, Rats, Receptors, Cholinergic, Sodium, Submandibular Gland
  • Author List

  • Morris AP; Fuller CM; Gallacher DV
  • Start Page

  • 195
  • End Page

  • 199
  • Volume

  • 211
  • Issue

  • 2