Regulation of angiogenesis by hypoxia: the role of microRNA.

Academic Article


  • Understanding the cellular pathways that regulate angiogenesis during hypoxia is a necessary aspect in the development of novel treatments for cardiovascular disorders. Although the pathways of angiogenesis have been extensively studied, there is limited information on the role of miRNAs in this process. miRNAs or their antagomirs could be used in future therapeutic approaches to regulate hypoxia-induced angiogenesis, so it is critical to understand their role in governing angiogenesis during hypoxic conditions. Although hypoxia and ischemia change the expression profile of many miRNAs, a functional role for a limited number of so-called hypoxamiRs has been demonstrated in angiogenesis. Here, we discuss the best examples that illustrate the role of hypoxamiRs in angiogenesis.
  • Keywords

  • 3' Untranslated Regions, Cardiovascular Diseases, Cell Hypoxia, Cell Line, Tumor, Endothelial Cells, Gene Expression Regulation, Humans, Hypoxia, Hypoxia-Inducible Factor 1, alpha Subunit, MicroRNAs, Neoplasms, Neovascularization, Pathologic, Signal Transduction, Vascular Endothelial Growth Factor A
  • Digital Object Identifier (doi)

    Author List

  • Madanecki P; Kapoor N; Bebok Z; Ochocka R; Collawn JF; Bartoszewski R
  • Start Page

  • 47
  • End Page

  • 57
  • Volume

  • 18
  • Issue

  • 1