Ivy/neurogliaform interneurons coordinate activity in the neurogenic niche.

Academic Article


  • Depolarization by the neurotransmitter GABA regulates adult neurogenesis. We found interneurons of the neurogliaform cell family to be a primary source of GABA for newborn neurons in mouse dentate gyrus. GABAergic depolarization occurred in concert with reduced synaptic inhibition of mature neurons, suggesting that the local circuitry coordinates the activation of new and pre-existing cells.
  • Published In


  • Action Potentials, Animals, Animals, Newborn, Bacterial Proteins, Biophysical Phenomena, Cell Adhesion Molecules, Neuronal, Electric Stimulation, Excitatory Amino Acid Antagonists, Extracellular Matrix Proteins, GABA Antagonists, Glutamic Acid, Green Fluorescent Proteins, Interneurons, Iontophoresis, Luminescent Proteins, Lysine, Mice, Mice, Inbred C57BL, Mice, Transgenic, Models, Neurological, Nerve Net, Nerve Tissue Proteins, Neural Inhibition, Neurogenesis, Neuropeptide Y, Nitric Oxide Synthase Type I, Patch-Clamp Techniques, Picrotoxin, Pro-Opiomelanocortin, Quinoxalines, Serine Endopeptidases, Stem Cell Niche, Synaptic Potentials, Time Factors, Valine
  • Digital Object Identifier (doi)

    Author List

  • Markwardt SJ; Dieni CV; Wadiche JI; Overstreet-Wadiche L
  • Start Page

  • 1407
  • End Page

  • 1409
  • Volume

  • 14
  • Issue

  • 11