The contribution of extrasynaptic signaling to cerebellar information processing

Academic Article


  • The diversity of synapses within the simple modular structure of the cerebellum has been crucial for study of the phasic extrasynaptic signaling by fast neurotransmitters collectively referred to as "spillover." Additionally, the accessibility of cerebellar components for in vivo recordings and their recruitment by simple behaviors or sensory stimuli has allowed for both direct and indirect demonstrations of the effects of transmitter spillover in the intact brain. The continued study of spillover in the cerebellum not only promotes our understanding of information transfer through cerebellar structures but also how extrasynaptic signaling may be regulated and interpreted throughout the CNS. © 2014 Springer Science+Business Media.
  • Digital Object Identifier (doi)

    Author List

  • Coddington LT; Nietz AK; Wadiche JI
  • Start Page

  • 513
  • End Page

  • 520
  • Volume

  • 13
  • Issue

  • 4