Carboxy-terminated poly(trimethylene propane trifumarate) (CT-TPF) oligomers were prepared as a mucoadhesive resin using different process variables. The process variables influence the condensation and molecular size and reactivity of the resin leading to different resins with variation in reactivity and molecular size. Four oligomers were prepared by refluxing at different temperatures, TPF1 (refluxing at 70-80°C for 15 min), TPF2 (refluxing at 80-100°C for 60 min), TPF3 (refluxing at 120-140°C for 15 min), and TPF4 (refluxing at 120-140°C for 30 min). A process parameter with refluxing at 120-140°C for 30 min resulted in a higher molecular weight fast setting resin, TPF4 (Mn 2700, Mw 2920 and polydispersity 1.08). Hydrogel adhesives were prepared using TPF4 resin, poly(ethylene glycol) dimethacrylate (PEGDMA, Mn 750), and n-vinyl pyrrolidone. TPF4 undergoes setting with setting time 8 ± 0.55 min with PEGDMA and n-vinyl pyrrolidone. The present hydrogel adhesive has higher shear holding time, 105 ± 3 s and peel strength 13 ± 0.002 kg/m at the speed of 0.022 m/s. The aging of the cured adhesive in the simulated biological fluids reveals gradual degradation due to the cross-linked nature of the cured adhesive. The cured hydrogel adhesive is cytocompatible with L929 fibroblast cells. © 2013 Wiley Periodicals, Inc. Adv Polym Technol 2013, 32, 20200; View this article online at wileyonlinelibrary.com. DOI 10.1002/adv.20200 © 2013 Wiley Periodicals, Inc.