Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk

Academic Article

Abstract

  • Background: The mechanism by which polymorphisms in the anti-aging protein klotho lead to increased disease risk is unknown. Results: In vitro, klotho-VS decreases homodimerization and increases heterodimerization with and activation of FGFR1c. Conclusion: Altered dimerization explains klotho-VS association with increased disease risk. Significance: Understanding how the VS variant leads to changes in klotho function will elucidate the role klotho plays in disease and lifespan.© 2013 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Zhou TBT; King GD; Chen CD; Abraham CR
  • Start Page

  • 36302
  • End Page

  • 36311
  • Volume

  • 288
  • Issue

  • 51