AMPA receptor-mediated EPSCs in rat neocortical layer II/III interneurons have rapid kinetics

Academic Article

Abstract

  • The properties of spontaneous and miniature (m) AMPA receptor-mediated excitatory postsynaptic currents (EPSCs) were studied in rat neocortical layer II/III fast spiking interneurons. Under optimal recording conditions, averaged mEPSCs had a 10-90% rise time of about 0.3 ms. The decay of averaged mEPSCs was double exponential with time constants of about 1 and 4 ms. Kinetics were observed to slow as series resistance increased. The amplitudes of mEPSCs were much smaller at +50 mV than at -50 mV indicating that the currents were inwardly rectifying. These results suggest that synaptic AMPA receptors on neocortical inhibitory interneurons have a deactivation time constant less than 1 ms which largely determines the decay of the synaptic currents. The receptors appear to lack GluR-2 subunits and may be Ca2+ permeable.
  • Authors

    Published In

  • Brain Research  Journal
  • Pubmed Id

  • 22983623
  • Author List

  • Zhou FM; Hablitz JJ
  • Start Page

  • 164
  • End Page

  • 167
  • Volume

  • 780
  • Issue

  • 1