Oestrogens and their promiscuous receptors: confronting reality.

Academic Article

Abstract

  • The binding sites of the oestrogen receptors alpha and beta have a structural requirement for ligands with two oxygen atoms (one of which is phenolic) spaced 11-12 A apart. They are open to many non-steroidal compounds, such as those from plants and the chemical industry. The importance of this interaction is the subject of current food safety research. This article examines the methods of assessment of oestrogenicity and their relationship to physiological events.
  • Published In

    Keywords

  • Biological Transport, Estrogens, Gene Expression Regulation, Humans, Inflammation, Oligonucleotide Array Sequence Analysis, Oxidants, RNA, Messenger, Receptors, Estrogen, Sulfotransferases
  • Author List

  • Barnes S
  • Start Page

  • 231
  • End Page

  • 236
  • Volume

  • 29
  • Issue

  • Pt 2