Thymus exosomes-like particles induce regulatory T cells

Academic Article

Abstract

  • Exosomes released from different types of cells have been proposed to contribute to intercellular communication. We report that thymic exosome-like particles (ELPs) released from cells of the thymus can induce the development of Foxp3+ regulatory T (Treg) cells in the lung and liver. Thymic ELPs also induce the conversion of thymic CD4+CD25- T cells into Tregs. Tregs induced by thymic ELPs suppress the proliferation of CD4 +CD25- T cells in vitro and in vivo. We further show that neutralization of TGF-β in ELPs partially reverses thymic ELP-mediated induction of CD4+Foxp3+ T cells in the lung and liver. This study demonstrates that thymic ELPs participate in the induction of Foxp3+ Tregs. Also, TGF-β of thymic ELPs might be required for the generation of Tregs in the peripheral tissues. Copyright © 2008 by The American Association of Immunologists, Inc.
  • Digital Object Identifier (doi)

    Author List

  • Wang GJ; Liu Y; Qin A; Shah SV; Deng ZB; Xiang X; Cheng Z; Liu C; Wang J; Zhang L
  • Start Page

  • 5242
  • End Page

  • 5248
  • Volume

  • 181
  • Issue

  • 8