Thymus exosomes-like particles induce regulatory T cells.

Academic Article

Abstract

  • Exosomes released from different types of cells have been proposed to contribute to intercellular communication. We report that thymic exosome-like particles (ELPs) released from cells of the thymus can induce the development of Foxp3(+) regulatory T (Treg) cells in the lung and liver. Thymic ELPs also induce the conversion of thymic CD4(+)CD25(-) T cells into Tregs. Tregs induced by thymic ELPs suppress the proliferation of CD4(+)CD25(-) T cells in vitro and in vivo. We further show that neutralization of TGF-beta in ELPs partially reverses thymic ELP-mediated induction of CD4(+)Foxp3(+) T cells in the lung and liver. This study demonstrates that thymic ELPs participate in the induction of Foxp3(+) Tregs. Also, TGF-beta of thymic ELPs might be required for the generation of Tregs in the peripheral tissues.
  • Published In

    Keywords

  • Animals, Female, Forkhead Transcription Factors, Liver, Lung, Mice, Mice, Inbred BALB C, T-Lymphocytes, Regulatory, Thymus Gland, Transforming Growth Factor beta
  • Author List

  • Wang G-J; Liu Y; Qin A; Shah SV; Deng Z-B; Xiang X; Cheng Z; Liu C; Wang J; Zhang L
  • Start Page

  • 5242
  • End Page

  • 5248
  • Volume

  • 181
  • Issue

  • 8