Involvement of envelope-glycoprotein glycans in HIV-1 biology and infection

Academic Article

Abstract

  • Infection of host cells with HIV-1 depends on a highly glycosylated virus envelope glycoprotein (Env) and host-cell receptors. Glycans participate substantially in Env folding and in the binding of virions to the host-cell surface and indirectly affect cellular uptake of HIV-1. Moreover, Env glycans could protect HIV-1 from host's neutralizing antibodies, but some glycans, on the other hand, represent targets for neutralizing antibodies. Variability of Env and its glycans in the HIV-1 strains from around the world as well as in patients during disease progression contributes substantially to further HIV-1 spreading in spite of the progress in basic HIV-1 research, vaccine development, and highly active antiretroviral therapy of HIV-1 infections. © L. Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland 2010.
  • Digital Object Identifier (doi)

    Author List

  • Raska M; Novak J
  • Start Page

  • 191
  • End Page

  • 208
  • Volume

  • 58
  • Issue

  • 3