Applications of LC-MS in the study of the uptake, distribution, metabolism and excretion of bioactive polyphenols from dietary supplements.

Academic Article


  • Specific and quantitative analyses of the bioactive components and their metabolites in body fluids are essential to assess the interaction between groups of compounds in dietary supplements and preparations of psychoactives. Reverse-phase LC separations combined with tandem mass spectrometry provide the necessary specificity and sensitivity. In this paper, applications of these methods are described for the analysis of isoflavones, salvinorin A, synephrine isomers and their metabolites in serum, urine and aqueous humor.
  • Published In

  • Life Sciences  Journal
  • Keywords

  • Animals, Chromatography, Liquid, Dietary Supplements, Diterpenes, Diterpenes, Clerodane, Dogs, Flavonoids, Mass Spectrometry, Phenols, Polyphenols, Psychotropic Drugs, Spectrometry, Mass, Electrospray Ionization, Synephrine
  • Digital Object Identifier (doi)

    Author List

  • Barnes S; Prasain JK; Wang C-C; Moore DR
  • Start Page

  • 2054
  • End Page

  • 2059
  • Volume

  • 78
  • Issue

  • 18