2D difference gel electrophoresis of prepubertal and pubertal rat mammary gland proteomes

Academic Article

Abstract

  • Rat mammary gland proteomes at day 21 (prepubertal) and day 50 (late puberty) were compared by 2D difference gel electrophoresis. Two-hundred fifty-one spots were significantly different (p < 0.05) in abundance. Peptide mass fingerprint analysis of a subset of these proteins identified two significantly over-represented classes including structural and blood proteins (increased), and metabolism-relevant proteins (reduced) in day 50 relative to day 21 glands. This is a first report of mammary gland proteome differences at these important breast cancer-relevant time-points. © 2008 American Chemical Society.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Kim H; Cope MB; Herring R; Robinson G; Wilson L; Page GP; Barnes S
  • Start Page

  • 4638
  • End Page

  • 4650
  • Volume

  • 7
  • Issue

  • 11