Chronic dietary kudzu isoflavones improve components of metabolic syndrome in stroke-prone spontaneously hypertensive rats.

Academic Article


  • The present study tested the long-term effects of dietary kudzu root extract supplementation on the regulation of arterial pressure, plasma glucose, and circulating cholesterol in stroke-prone spontaneously hypertensive rats (SP-SHR). Female SP-SHR were maintained for 2 months on a polyphenol-free diet, with or without the addition of 0.2% kudzu root extract. Half of the rats in each diet group were ovariectomized, whereas the other half remained intact. Following 2 months on the diets, the 0.2% kudzu root extract supplementation (compared to control diet) significantly lowered arterial pressure (11-15 mmHg), plasma cholesterol, fasting blood glucose (20-30%), and fasting plasma insulin in both the ovariectomized and intact SP-SHR. These results indicate that long-term dietary kudzu root extract supplementation can improve glucose, lipid, and blood pressure control in intact and ovariectomized SP-SHR.
  • Keywords

  • Animals, Blood Glucose, Blood Pressure, Cholesterol, Disease Models, Animal, Female, Humans, Isoflavones, Metabolic Syndrome, Plant Extracts, Pueraria, Random Allocation, Rats, Rats, Inbred SHR, Stroke
  • Digital Object Identifier (doi)

    Author List

  • Peng N; Prasain JK; Dai Y; Moore R; Arabshahi A; Barnes S; Carlson S; Wyss JM
  • Start Page

  • 7268
  • End Page

  • 7273
  • Volume

  • 57
  • Issue

  • 16