T cell induction of macrophage IL-1 during antigen presentation. Characterization of a lymphokine mediator and comparison of T(H)1 and T(H)2 subsets

Academic Article

Abstract

  • We described in a previous study two pathways by which Th cells induced macrophage membrane IL-1(mIL-1) during Ag presentation. One pathway was lymphokine-independent and mediated by cell-cell contact. The second was lymphokine-dependent. We have now characterized this lymphokine and show that it belongs to the TNF family of proteins. All T(H)1 and most T(H)2 clones produced the lymphokine, although T(H)1 levels were markedly greater. Both types of clones also induced macrophage mIL-1 by cell-cell contact (i.e., in the absence of lymphokine release). Examination of macrophages by in situ hybridization showed that both IL-1α and IL-1β mRNA were coordinately induced during Ag presentation to either T(H)1 or T(H)2 clones.
  • Published In

    Author List

  • Weaver CT; Duncan LM; Unanue ER
  • Start Page

  • 3469
  • End Page

  • 3476
  • Volume

  • 142
  • Issue

  • 10