Restricted clonal expression of IL-2 by naive T cells reflects differential dynamic interactions with dendritic cells

Academic Article

Abstract

  • Limited frequencies of T cells express IL-2 in primary antigenic responses, despite activation marker expression and proliferation by most clonal members. To define the basis for restricted IL-2 expression, a videomicroscopic system and IL-2 reporter transgenic model were used to characterize dendritic cell (DC)-T cell interactions. T cells destined to produce IL-2 required prolonged interactions with DCs, whereas most T cells established only transient interactions with DCs and were activated, but did not express IL-2. Extended conjugation of T cells with DCs was not always sufficient to initiate IL-2 expression. Thus, there is intrinsic variability in clonal T cell populations that restricts IL-2 commitment, and prolonged engagement with mature DCs is necessary, but not sufficient, for IL-2 gene transcription.
  • Digital Object Identifier (doi)

    Pubmed Id

  • 26469947
  • Author List

  • Hurez V; Saparov A; Tousson A; Fuller MJ; Kubo T; Oliver J; Weaver BT; Weaver CT
  • Start Page

  • 123
  • End Page

  • 132
  • Volume

  • 198
  • Issue

  • 1