Immune intervention strategies for HIV-1 infection of humans in the SIV macaque model

Academic Article


  • Studies in the SIVmac macaque model have demonstrated that the extent of virus-specific CD4+ and CD8+ T-cell responses induced by vaccination prior to virus-challenge exposure correlate with viremia containment following establishment of infection. These findings led to the hypothesis that active immunization with vaccines able to induce virus-specific T-cell responses following the establishment of infection could also ameliorate the virological outcome. Here, we will review the relative effect of ART and vaccination during primary SIVmac infection of macaques.
  • Published In

  • Vaccine  Journal
  • Digital Object Identifier (doi)

    Author List

  • Franchini G; Nacsa J; Hel Z; Tryniszewska E
  • Volume

  • 20
  • Issue

  • SUPPL. 4