Inhalation exposure model of hydrogen sulfide (H2S)-induced hypometabolism in the male Sprague-Dawley rat

Academic Article

Abstract

  • © 2015 Elsevier Inc. All rights reserved. Hydrogen sulfide (H2S) has been accepted as a physiologically relevant cell-signaling molecule with both toxic and beneficial effects depending on its concentration in mammalian tissues. Notably, exposure to H2S in breathable air has been shown to decrease aerobic metabolism and induce a reversible hypometabolic-like state in laboratory rodent models. Herein, we describe an experimental exposure setup that can be used to define the reversible cardiovascular and metabolic physiology of rodents (rats) during H2S-induced hypometabolism and following recovery.
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    Published In

    Digital Object Identifier (doi)

    Author List

  • Stein A; Kraus DW; Doeller JE; Bailey SM
  • Start Page

  • 19
  • End Page

  • 35
  • Volume

  • 555