Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation

Academic Article


  • Recent progress in our understanding of mechanisms by which the immunosuppressive cytokine interleukin-10 (IL-10) participates in an ever-increasing diversity of T-cell lineages to maintain immune homeostasis has broadened the framework for defining regulatory and effector T cells and has blurred the lines between them. In this review, we highlight established and emerging roles for IL-10 produced by distinct CD4+ T-cell lineages that underlie its non-redundant role in curbing immune responses to the intestinal microbiota at steady state and its role to limit T-cell-driven inflammation in responses to pathogens. © 2008 The Authors.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Maynard CL; Weaver CT
  • Start Page

  • 219
  • End Page

  • 233
  • Volume

  • 226
  • Issue

  • 1