IL-9 as a mediator of Th17-driven inflammatory disease

Academic Article

Abstract

  • We report that like other T cells cultured in the presence of transforming growth factor (TGF) β, Th17 cells also produce interleukin (IL) 9. Th17 cells generated in vitro with IL-6 and TGF-β as well as purified ex vivo Th17 cells both produced IL-9. To determine if IL-9 has functional consequences in Th17-mediated inflammatory disease, we evaluated the role of IL-9 in the development and progression of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. The data show that IL-9 neutralization and IL-9 receptor deficiency attenuates disease, and this correlates with decreases in Th17 cells and IL-6-producing macrophages in the central nervous system, as well as mast cell numbers in the regional lymph nodes. Collectively, these data implicate IL-9 as a Th17-derived cytokine that can contribute to inflammatory disease. © 2009 Nowak et al.
  • Digital Object Identifier (doi)

    Author List

  • Nowak EC; Weaver CT; Turner H; Begum-Haque S; Becher B; Schreiner B; Coyle AJ; Kasper LH; Noelle RJ
  • Start Page

  • 1653
  • End Page

  • 1660
  • Volume

  • 206
  • Issue

  • 8