Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines.

Academic Article

Abstract

  • Chemokines and chemokine receptors have been shown to be involved in metastatic process of prostate cancer (PCa). In this study, we show primary PCa tissues and cell lines (LNCaP and PC3) express CXCR5, a specific chemokine receptor for CXCL13. Expression of CXCR5 was significantly higher (p < 0.001) in PCa cases than compared to normal match (NM) tissues. CXCR5 intensity correlated (R(2) = 0.97) with Gleason score. While prostate tumor tissues with Gleason scores >or= 7, displayed predominantly nuclear CXCR5 expression patterns, PCa specimens with Gleason scores
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    Keywords

  • Cell Adhesion, Cell Movement, Chemokine CXCL13, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Humans, Immunoenzyme Techniques, Male, Matrix Metalloproteinases, Neoplasm Invasiveness, Neoplasm Staging, Prostate, Prostatic Hyperplasia, Prostatic Neoplasms, RNA, Messenger, Receptors, CXCR5, Reverse Transcriptase Polymerase Chain Reaction, Tumor Cells, Cultured
  • Digital Object Identifier (doi)

    Author List

  • Singh S; Singh R; Singh UP; Rai SN; Novakovic KR; Chung LWK; Didier PJ; Grizzle WE; Lillard JW
  • Start Page

  • 2288
  • End Page

  • 2295
  • Volume

  • 125
  • Issue

  • 10